rs1071803

This is a missense variant variant.

▶

GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

trem-like transcript 4 protein measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.71
p 3.0e-190
N 3,301
Large GWAS
European

protein shisa-3 homolog measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.71
p 6.0e-185
N 3,301
Large GWAS
European

secretoglobin family 1C member 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.63
p 4.0e-141
N 3,301
Large GWAS
European

ameloblastin measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.56
p 4.0e-108
N 3,301
Large GWAS
European

di-N-acetylchitobiase measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.53
p 3.0e-94
N 3,301
Large GWAS
European

insulin growth factor-like family member 4 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.47
p 2.0e-72
N 3,301
Large GWAS
European

protein EVI2B measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.40
p 2.0e-51
N 3,301
Large GWAS
European

secreted Ly-6/uPAR-related protein 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele C
OR 0.36
p 7.0e-42
N 3,301
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis
AssociationN=638Dorothea Buck et al.(2013)· Annals of Neurology

A genome-wide association study identified five SNPs in the immunoglobulin heavy chain locus (IGHC) on chromosome 14q32.33 associated with the IgG index, a measure of intrathecal IgG synthesis in multiple sclerosis patients. The strongest association was rs10136766 (p = 7.5 × 10⁻¹⁶), which explained 8.9% of variance and was associated with the GM21* haplotype. These SNPs showed no association with MS susceptibility itself.

Traits studied:IgG indexIntrathecal IgG synthesisMultiple sclerosis
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…