rs10743612

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hip geometry

Faber BG et al. “The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.” Human Molecular Genetics 34(3):207-217 (2025)
Allele A
OR 0.06
p 2.0e-13
N 43,485
Large GWAS
multi-ancestry
Baird DA et al. “Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies” Journal of Bone and Mineral Research (2019)
Allele A
OR 0.09
p 3.0e-12
N 15,934
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies
Meta-analysisN=15,934Baird DA et al.(2019)· Journal of Bone and Mineral Research

A GWAS meta-analysis of 15,934 individuals identified 9 SNPs across 8 loci associated with hip shape phenotypes derived from DXA scans. Five SNPs were associated with hip shape mode 1 (HSM1) at genome-wide significance (p < 5×10⁻⁹), three with HSM2, and one with HSM5. Most loci were close to genes involved in endochondral bone formation (SOX9, PTHLH, FGFR4, NKX3-2, DICER1, RUNX1, HHIP) and also associated with height. Three SNPs showed associations with hip osteoarthritis and one with hip fracture risk.

Traits studied:Femoral neck bone mineral densityHeightHip fractureHip osteoarthritisHip shapeWaist circumference
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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