rs1075534

This variant is located in the PPP3CC gene.

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Research that mentions this SNP (1)

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Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults
AssociationN=102Zi-Hong He et al.(2010)· European Journal of Applied Physiology

This study examined 55 polymorphisms in five calcineurin genes (PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2) in 102 young Chinese men for associations with cardiac phenotypes at baseline and training responsiveness after 18 weeks of endurance training. Key findings: rs3763679 in PPP3CB was significantly associated with resting heart rate at baseline; rs1879793, rs1075534, rs7430, rs2461483, and rs10108011 in PPP3CC were associated with cardiac output/stroke volume response to exercise; rs1407877 in PPP3R2 was associated with ejection fraction response at 50W.

Traits studied:Cardiac outputCardiac phenotypesEjection fractionLeft ventricular massResting heart rateStroke volumeTraining responsiveness
PubMedDOIMetascience Observatory

About PPP3CC

Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

View all PPP3CC variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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