rs10762577

This variant is located in the ADK gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

coronary artery calcification

Kavousi M et al. “Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.” Nature Genetics 55(10):1651-1664 (2023)

Allele A

OR 0.11

p 4.0e-8

N 36,720

Large GWAS

multi-ancestry

About ADK

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

View all ADK variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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