rs1078643

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

colorectal cancer

Fernandez-Rozadilla C et al. “Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.” Nature Genetics 55(1):89-99 (2023)

Allele A

OR 0.09

p 2.0e-27

N 254,791

Large GWAS

multi-ancestry

Tian J et al. “Developing an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies.” Genome Medicine 16(1):81 (2024)

Allele A

OR —

β 0.080

p 4.0e-13

N 839,703

Large GWAS

multi-ancestry

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.09

p 1.0e-9

N 637,693

Large GWAS

multi-ancestry

Law PJ et al. “Association analyses identify 31 new risk loci for colorectal cancer susceptibility.” Nature Communications 10(1):2154 (2019)

Allele A

OR 1.09

p 4.0e-11

N 92,967

Large GWAS

European

Lu Y et al. “Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.” Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 29(2):477-486 (2020)

Allele A

OR 1.13

p 2.0e-13

N 72,272

Large GWAS

multi-ancestry

Lu Y et al. “Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.” Gastroenterology 156(5):1455-1466 (2019)

Allele A

OR 1.13

p 8.0e-13

N 70,506

Large GWAS

East Asian

colorectal cancer, colorectal adenoma

Huyghe JR et al. “Discovery of common and rare genetic risk variants for colorectal cancer.” Nature Genetics 51(1):76-87 (2019)

Allele A

OR 1.08

p 7.0e-12

N 125,478

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs1078643

GWAS Catalog Trait Associations (2)

colorectal cancer

colorectal cancer, colorectal adenoma

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