rs10791824

This variant is located in the OVOL1 gene.

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atopic eczema

Budu-Aggrey A et al. “European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.” Nature Communications 14(1):6172 (2023)
Allele G
OR 1.07
p 1.0e-105
N 864,982
Meta-analysisLarge GWAS
European
Pasanen A et al. “Identifying Atopic Dermatitis Risk Loci in 1,094,060 Individuals with Subanalysis of Disease Severity and Onset.” The Journal of Investigative Dermatology 144(11):2417-2425 (2024)
Allele G
OR —
p 3.0e-32
N 1,094,060
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.09
p 6.0e-10
N 649,402
Large GWAS
multi-ancestry
Paternoster L et al. “Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature Genetics 47(12):1449-1456 (2015)
Allele G
OR 1.12
p 2.0e-19
N 116,863
Large GWAS
multi-ancestry

Fc receptor-like protein 2 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.06
p 3.0e-38
N 47,745
Large GWAS
European

Eczematoid dermatitis

Grosche S et al. “Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4.” Nature Communications 12(1):6618 (2021)
Allele G
OR 1.13
p 7.0e-27
N 400,449
Large GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.09
p 3.0e-12
N 394,626
Large GWAS
European

allergic disease

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele G
OR 0.04
p 2.0e-16
N 477,968
Large GWAS
European

allergic disease, age at onset

Ferreira MAR et al. “Age-of-onset information helps identify 76 genetic variants associated with allergic disease.” Plos Genetics 16(6):e1008725 (2020)
Allele G
OR 0.04
p 2.0e-16
N 117,130
Large GWAS
European

brorin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.03
p 4.0e-12
N 47,745
Large GWAS
European

asthma

Zhu Z et al. “Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.” The European Respiratory Journal 54(6) (2019)
Allele G
OR 1.04
p 4.0e-11
N 394,283
Large GWAS
multi-ancestry

About OVOL1

This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

View all OVOL1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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