rs10824026

This is a intron variant variant in the SYNPO2L-AS1 gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Christophersen IE et al. “Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.” Nature Genetics 49(6):946-952 (2017)
Allele A
OR 1.13
p 8.0e-11
N 118,755
Large GWAS
European
Ellinor PT et al. “Meta-analysis identifies six new susceptibility loci for atrial fibrillation.” Nature Genetics 44(6):670-675 (2012)
Allele A
OR 1.15
p 4.0e-9
N 59,133
Meta-analysisLarge GWAS
European
▶

Research that mentions this SNP (1)

▶
Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals
AssociationN=17,325Jason D. Roberts et al.(2016)· JAMA Cardiology

This genome-wide admixture analysis of three population-based cohorts (CHS, ARIC, Health ABC; n=17,325) investigated whether 9 known atrial fibrillation (AF) SNPs explain the paradoxically higher AF risk in Whites compared to Blacks. Using Cox proportional hazards models, rs10824026 (in SYNPO2L/MYOZ1) significantly mediated 11.4% (95% CI 2.9-29.9%) and 31.7% (95% CI 16.0-53.0%) of the excess AF risk in Whites in CHS and ARIC respectively. Admixture mapping across 4,938 Black participants identified no loci reaching genome-wide significance (p<7×10⁻⁶), suggesting the racial differential in AF risk is driven by multiple genetic and/or environmental factors rather than single variants.

Traits studied:Atrial fibrillation
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…