rs10828723

This is a intron variant variant in the PRTFDC1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

leukocyte quantity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele T

OR 0.05

p 4.0e-42

N 546,038

Major Consortium StudyLarge GWAS

multi-ancestry

erythrocyte attribute

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)

Allele C

OR 0.09

p 2.0e-33

N 39,459

Large GWAS

European

lymphocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)

Allele C

OR 0.03

p 9.0e-17

N 171,643

Large GWAS

European

About PRTFDC1

Enables protein homodimerization activity. Predicted to be involved in purine ribonucleoside salvage. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

View all PRTFDC1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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