rs10851839

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

FEV/FVC ratio

Wain LV et al. “Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.” Nature Genetics 49(3):416-425 (2017)

Allele A

OR 0.07

p 1.0e-24

N 48,943

Large GWAS

European

smoking status measurement, chronic obstructive pulmonary disease

Kim W et al. “Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.” American Journal of Epidemiology 190(5):875-885 (2021)

Allele T

OR —

p 1.0e-23

N 200,766

Large GWAS

European

spontaneous coronary artery dissection

Adlam D et al. “Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.” Nature Genetics 55(6):964-972 (2023)

Allele A

OR 1.32

p 6.0e-11

N 11,209

Meta-analysisLarge GWAS

European

chronic obstructive pulmonary disease

Kim W et al. “Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.” American Journal of Epidemiology 190(5):875-885 (2021)

Allele T

OR 1.14

p 3.0e-14

N 200,766

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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