rs10855058

This variant is located in the KLF8 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate specific antigen amount

Kachuri L et al. “Genetically adjusted PSA levels for prostate cancer screening.” Nature Medicine 29(6):1412-1423 (2023)
Allele A
OR 0.02
p 8.0e-9
N 95,768
Large GWAS
multi-ancestry
Hoffmann TJ et al. “Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.” Nature Communications 8:14248 (2017)
Allele A
OR 0.03
p 1.0e-8
N 28,503
Large GWAS
multi-ancestry

About KLF8

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

View all KLF8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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