rs10857788

This variant is located in the SYPL2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele A

OR 12.12

p 8.0e-34

N 1,508,659

Large GWAS

multi-ancestry

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele A

OR 0.00

p 2.0e-20

N 765,348

Large GWAS

multi-ancestry

About SYPL2

Involved in substantia nigra development. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SYPL2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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