rs10861798

This is a intron variant variant in the SYT1 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

grip strength measurement

Willems SM et al. “Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.” Nature Communications 8:16015 (2017)

Allele A

OR 0.15

p 1.0e-10

N 142,035

Large GWAS

European

About SYT1

This gene encodes a member of the synaptotagmin protein family. The synaptotagmins are integral membrane proteins of synaptic vesicles that serve as calcium sensors in the process of vesicular trafficking and exocytosis. The encoded protein participates in triggering neurotransmitter release at the synapse in response to calcium binding. Mutations in this gene are associated with Baker-Gordon syndrome. [provided by RefSeq, Jan 2023]

View all SYT1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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