rs10862089

This variant is located in the OTOGL gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Vertigo

Chen SP et al. “A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.” Communications Biology 7(1):1034 (2024)

Allele T

OR 1.22

p 1.0e-19

N 1,003,399

Large GWAS

multi-ancestry

Skuladottir AT et al. “A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.” Communications Biology 4(1):1148 (2021)

Allele T

OR 1.11

p 1.0e-13

N 942,613

Meta-analysisLarge GWAS

European

peripheral vertigo, central nervous system origin vertigo

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.37

p 1.0e-11

N 57,413

Major Consortium StudyLarge GWAS

Hispanic or Latin American

vestibular disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.20

p 7.0e-21

N 433,013

Major Consortium StudyLarge GWAS

European

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ClinVar annotation

Benign★★★☆

6 submitters3 publications

not specified; not provided; Uterine carcinosarcoma; Cholangiocarcinoma; Familial cancer of breast

View on ClinVar →

About OTOGL

The protein encoded by this gene belongs to the otogelin family. This gene is expressed in the inner ear of vertebrates with the highest level of expression seen at the embryonic stage and lowest in adult. Knockdown studies in zebrafish suggest that this gene is essential for normal inner ear function. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2012]