rs10865035

This variant is located in the LINC01104 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

marginal zone B- and B1-cell-specific protein measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 5.0e-15
N 47,745
Large GWAS
European

Fc receptor-like protein 5 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.03
p 6.0e-12
N 47,745
Large GWAS
European

intelligence

Savage JE et al. “Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.” Nature Genetics 50(7):912-919 (2018)
Allele A
OR 6.06
p 1.0e-9
N 269,867
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (2)

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Novel Rheumatoid Arthritis Susceptibility Locus at 22q12 Identified in an Extended UK Genome‐Wide Association Study
AssociationN=8,305Gisela Orozco et al.(2014)· Arthritis &amp; Rheumatology

This extended UK genome-wide association study identified a novel rheumatoid arthritis susceptibility locus at 22q12 (rs1043099, P = 6.9 × 10⁻⁹, OR = 0.84) in 3,034 cases and 5,271 controls, and confirmed 16 previously known RA loci, strengthening evidence for genetic contributors to RA in the UK population.

Traits studied:Rheumatoid arthritis
PubMedDOIMetascience Observatory
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Association of AFF1 rs340630 and AFF3 rs10865035 polymorphisms with systemic lupus erythematosus in a Chinese population
AssociationN=1,843Han Cen et al.(2012)· Immunogenetics

Case-control study examining association of AFF1 rs340630 and AFF3 rs10865035 with systemic lupus erythematosus (SLE) in 868 Chinese patients and 975 healthy controls. AFF3 rs10865035 showed significant association with SLE (A vs G: OR 1.26, 95% CI 1.11-1.44, p=4.81×10⁻⁴), while AFF1 rs340630 showed no significant association. Findings suggest AFF3 is a common susceptibility gene for multiple autoimmune disorders.

Traits studied:Juvenile idiopathic arthritisRheumatoid arthritisSystemic lupus erythematosusType 1 diabetes
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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