rs10868235

This is a intron variant variant in the NTRK2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neurotrophin-3 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.08
p 2.0e-41
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style
AssociationN=252Saeko Aizawa et al.(2015)· Brain and Behavior

A genetic association study in 252 healthy Japanese controls examining SNP polymorphisms in BDNF and NTRK2 genes and their association with stress-coping strategies, ego aptitude, and social adaptation. BDNF rs6265 (Val/Met) showed significant associations with emotion-focused coping, seeking social support, self-control, and distancing. Five NTRK2 SNPs (rs11140800, rs1187286, rs1867283, rs1147198, rs10868235) demonstrated significant associations with cognitive strategies, problem-solving, and multiple ego-related factors.

Traits studied:AnxietyDepressionEgo aptitudeEmotion-focused copingProblem-focused copingSocial adaptationStress-coping style
PubMedDOIMetascience Observatory

About NTRK2

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

View all NTRK2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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