rs10878269
This is a intron variant variant in the MSRB3 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
snoring measurement
Campos AI et al. “Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.” Nature Communications 11(1):817 (2020)
Allele C
OR 0.01
p 5.0e-18
N 407,066
Major Consortium StudyLarge GWAS
European
Jansen PR et al. “Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.” Nature Genetics 51(3):394-403 (2019)
Allele C
OR 1.04
p 4.0e-13
N 359,916
Large GWAS
European
cerebral cortex area attribute
Shadrin AA et al. “Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.” Neuroimage 244:118603 (2021)
Allele T
OR —
p 1.0e-17
N 35,657
Large GWAS
European
About MSRB3
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
View all MSRB3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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