rs10895304

This is a downstream gene variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neutrophil collagenase level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.08
p 6.0e-29
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic polymorphisms in the MMP‐7 gene and breast cancer survival
AssociationN=1,079Alicia Beeghly‐Fadiel et al.(2009)· International Journal of Cancer

This population-based survival study of 1,079 Chinese breast cancer patients found that two common MMP-7 polymorphisms significantly predict breast cancer prognosis. Patients homozygous for the rs11568818 rare allele (G) had substantially worse overall survival (HR: 6.7, 95% CI: 2.4-18.6), while rs11225297 T allele carriers showed improved survival in a dose-response manner (AT: HR 0.7; TT: HR 0.3).

Traits studied:Breast cancer prognosisBreast cancer survivalDisease-free survivalOverall survival
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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