rs10917661
This is a stop gained variant in the FCGR2B gene.
▶Research that mentions this SNP (1)
▶RETRACTED ARTICLE: Gln50Ter Polymorphism of Fcγ receptor IIB gene associated with genetic susceptibility to human systemic lupus erythematosus in Chinese populationsAssociationN=435Faming Pan et al.(2007)· Archives of Dermatological Research
Family-based association study of 119 SLE patients and 316 family members from 95 Chinese nuclear families investigating the Fc gamma RIIB gene. The Gln50Ter polymorphism (rs10917661) was significantly associated with SLE susceptibility in additive (Z=3.444, P=0.00057), dominant (Z=2.619, P=0.0088), and recessive (Z=3.072, P=0.0021) genetic models. TDT/SDT analysis showed excess transmission of the 50Ter allele to affected offspring (chi-square=10.88, P=0.0013).
About FCGR2B
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
View all FCGR2B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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