rs10917696
This variant is located in the RGS5 gene.
▶Research that mentions this SNP (1)
▶RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patientsAssociationN=99Malgorzata Labuda et al.(2013)· Pediatric Pulmonology
This association study found that the rs10917696 C/T polymorphism in the RGS5 gene is significantly associated with bronchodilator responsiveness to albuterol in 99 asthmatic children (P=0.008, remaining significant with P=0.005 in multivariate analysis). The authors identified an additive effect between RGS5 rs10917696 and PDE4D rs1544791, with carriers of two risk alleles (C and G) showing the lowest FEV1% change (4.6±1.3%), one risk allele showing 8.1±0.7%, and no risk alleles showing 13.5±2.4% (P=0.001).
About RGS5
This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]
View all RGS5 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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