rs10923724

This is a upstream gene variant variant.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

BMI-adjusted waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele T

OR 0.03

p 1.0e-89

N 315,284

Meta-analysisLarge GWAS

European

Lotta LA et al. “Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.” Jama 320(24):2553-2563 (2018)

Allele T

OR 0.04

p 1.0e-87

N 660,648

Large GWAS

European

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele T

OR 0.04

p 7.0e-12

N 118,949

Meta-analysisLarge GWAS

multi-ancestry

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele T

OR 0.02

p 2.0e-45

N 697,734

Meta-analysisLarge GWAS

European

Allele T

OR —

p 5.0e-8

N 663,598

Large GWAS

European

body mass index

Koskeridis F et al. “Pleiotropic genetic architecture and novel loci for C-reactive protein levels.” Nature Communications 13(1):6939 (2022)

Allele T

OR 0.01

p 3.0e-15

N 694,649

Large GWAS

European

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)

Allele T

OR 0.01

p 1.0e-14

N 806,834

Meta-analysisLarge GWAS

European

Sidorenko J et al. “Genetic architecture reconciles linkage and association studies of complex traits.” Nature Genetics 56(11):2352-2360 (2024)

Allele T

OR 0.01

p 8.0e-12

N 650,000

Large GWAS

European

Akiyama M et al. “Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.” Nature Genetics 49(10):1458-1467 (2017)

Allele T

OR 0.01

p 2.0e-8

N 158,284

Large GWAS

multi-ancestry

BMI-adjusted waist circumference

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele T

OR 0.04

p 2.0e-10

N 122,328

Meta-analysisLarge GWAS

multi-ancestry

BMI-adjusted waist-hip ratio, physical activity measurement

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele T

OR 0.03

p 7.0e-9

N 156,653

Meta-analysisLarge GWAS

multi-ancestry

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Research that mentions this SNP (1)

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Genome‐Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex‐Specific Adiposity Loci in Mexican Americans

AssociationN=1,417Chuan Gao et al.(2018)· Obesity

This genome-wide association study (GWAS) in 1,417 Mexican Americans identified six loci with genome-wide significant associations with fat deposition phenotypes (visceral and subcutaneous adipose tissue). The strongest signal was rs2185405 in GLIS3 associated with visceral adipose tissue (P=1.98×10⁻⁸), with carriers of the minor allele showing 19.91 cm² less visceral fat. Sex-stratified analyses revealed SRFBP1 and SNX13 loci with male-specific associations, and SNP-sex interaction analyses identified significant variants in TMCC1, PAPPA2, and TBX15.

Traits studied:AdiposityBody mass indexInsulin resistanceSubcutaneous adipose tissueVisceral adipose tissueVisceral-subcutaneous ratio

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs10923724

GWAS Catalog Trait Associations (5)

BMI-adjusted waist-hip ratio

waist-hip ratio

body mass index

BMI-adjusted waist circumference

BMI-adjusted waist-hip ratio, physical activity measurement

Research that mentions this SNP (1)

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