rs10937913

This is a intron variant variant in the TNIP2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

aging, epigenetic status

Lu AT et al. “GWAS of epigenetic aging rates in blood reveals a critical role for TERT.” Nature Communications 9(1):387 (2018)

Allele A

OR 0.59

p 2.0e-11

N 8,393

Large GWAS

multi-ancestry

About TNIP2

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

View all TNIP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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