rs10958409

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain aneurysm

Bilguvar K et al. “Susceptibility loci for intracranial aneurysm in European and Japanese populations.” Nature Genetics 40(12):1472-7 (2008)
Allele A
OR 1.36
p 1.0e-10
N 7,856
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China
AssociationN=1,282Chun Wang et al.(2012)· Human Genetics

This population-based case-control study examined associations between three GWAS-identified SNPs (rs700651, rs10958409, rs1333040) and stroke risk in 451 Chinese female stroke cases and 831 controls. The study replicated associations of rs10958409 (OR 1.54, 95% CI 1.20-1.98 under additive model) and rs1333040 (OR 2.16, 95% CI 1.19-3.95 under dominant model) with stroke risk, particularly hemorrhagic stroke. Combined oral contraceptive (COC) use with risk alleles further elevated stroke risk, with COC users carrying rs10958409 GA/AA or rs1333040 CT/TT genotypes showing 2.59-fold and 4.24-fold increased overall stroke risk, and up to 15-fold increased hemorrhagic stroke risk.

Traits studied:Cerebral hemorrhageCerebral infarctionHemorrhagic strokeIntracranial aneurysmIschemic strokeStrokeSubarachnoid hemorrhage
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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