rs10962692

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

ovarian carcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)
Allele G
OR 1.34
p 5.0e-64
N 85,426
Large GWAS
European

ovarian serous carcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)
Allele G
OR 1.33
p 3.0e-43
N 54,990
Large GWAS
European
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Research that mentions this SNP (1)

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A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants
AssociationN=25,537Sehee Kim et al.(2019)· International Journal of Cancer

A comprehensive gene-environment interaction study in ovarian cancer examining 28 genome-wide significant variants and 7 environmental risk factors (oral contraceptive use, parity, tubal ligation, breastfeeding, menopausal hormone therapy, BMI, endometriosis) in 9,971 cases and 15,566 controls. The strongest multiplicative interaction identified was between rs13255292 and OCP use (P = 3.48 × 10⁻⁴), with differential protective effects by genotype and duration of use, though no interactions remained significant after multiple testing correction.

Traits studied:Epithelial ovarian cancerFallopian tube cancerOvarian cancerPrimary peritoneal cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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