rs10968577
This is a intron variant variant in the LINGO2 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele T
OR —
β 0.025
p 1.0e-16
N 309,889
Large GWAS
European
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele T
OR 0.03
p 3.0e-11
N 123,097
Meta-analysisLarge GWAS
multi-ancestry
clinical and behavioural ideal cardiovascular health
Huang RDL et al. “Genome-wide and phenome-wide analysis of ideal cardiovascular health in the VA Million Veteran Program.” Plos One 17(5):e0267900 (2022)
Allele C
OR —
β 0.040
p 5.0e-9
N 142,404
Major Consortium StudyLarge GWAS
multi-ancestry
physical activity measurement, body mass index
Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)
Allele T
OR 0.03
p 4.0e-12
N 161,368
Meta-analysisLarge GWAS
multi-ancestry
About LINGO2
Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and synaptic membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all LINGO2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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