rs10987006

This is a regulatory region variant variant in the PBX3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sleep duration trait

Doherty A et al. “GWAS identifies 14 loci for device-measured physical activity and sleep duration.” Nature Communications 9(1):5257 (2018)

Allele C

OR 0.03

p 7.0e-9

N 91,105

Large GWAS

European

About PBX3

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including embryonic organ development; eye development; and nervous system development. Predicted to act upstream of or within several processes, including adult locomotory behavior; dorsal spinal cord development; and regulation of respiratory gaseous exchange by nervous system process. Predicted to be located in chromatin. Predicted to be part of transcription regulator complex. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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