rs10995245
This variant is located in the LOC105378327 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
narcolepsy-cataplexy syndrome
Ollila HM et al. “Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.” Nature Communications 14(1):2709 (2023)
Allele A
OR 0.15
p 3.0e-12
N 90,929
Large GWAS
multi-ancestry
Han F et al. “Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.” Plos Genetics 9(10):e1003880 (2013)
Allele A
OR 1.23
p 1.0e-11
N 3,186
Large GWAS
multi-ancestry
asthma
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.04
p 1.0e-9
N 625,448
Large GWAS
multi-ancestry
Ferreira MAR et al. “Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.” American Journal of Human Genetics 104(4):665-684 (2019)
Allele A
OR 1.04
p 1.0e-8
N 341,215
Large GWAS
European
asthma, Eczematoid dermatitis, allergic rhinitis
Johansson Å et al. “Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.” Human Molecular Genetics 28(23):4022-4041 (2019)
Allele A
OR 1.03
p 2.0e-9
N 346,545
Major Consortium StudyLarge GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…