rs11001819
This variant is located in the LRMDA gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
forced expiratory volume
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele G
OR 0.01
p 3.0e-18
N 373,397
Large GWAS
European
Wain LV et al. “Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.” The Lancet. Respiratory Medicine 3(10):769-81 (2015)
Allele G
OR 0.11
p 1.0e-8
N 29,303
Major Consortium StudyLarge GWAS
European
pulmonary function measurement, forced expiratory volume
Soler Artigas M et al. “Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.” Nature Genetics 43(11):1082-90 (2011)
Allele G
OR 0.03
p 3.0e-12
N 48,201
Large GWAS
European
About LRMDA
This gene encodes a leucine-rich repeat protein. The encoded protein is thought to play a role in melanocyte differentiation. Mutations in this gene have been associated with autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
View all LRMDA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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