rs11030096
This is a intron variant variant in the BDNF-AS gene.
▶Research that mentions this SNP (3)
▶No association of genetic variants in BDNF with major depression: A meta‐ and gene‐based analysisMeta-analysisJoseph P. Gyekis et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Meta-analysis of 28 studies (range 38-7,173 participants) found no significant association between BDNF genetic variants and major depressive disorder. Val66Met (rs6265) showed OR=0.96 (95% CI: 0.89-1.05; P=0.402), and gene-based analysis of 17 total BDNF SNPs indicated no cumulative association with MDD (all P>0.21).
▶Influence of neurexin 1 (NRXN1) polymorphisms in clozapine responseReviewRenan P. Souza et al.(2010)· Human Psychopharmacology: Clinical and Experimental
This systematic review of 98 studies examined biological predictors of clozapine response in treatment-resistant schizophrenia patients. Of 379 different gene variants investigated across 70 genetic studies, only three variants (DRD3 Ser9Gly rs6280, HTR2A His452Tyr, and GNB3 C825T) achieved independent replication. Non-genetic predictors included higher prefrontal cortical volumes and lower HVA:5-HIAA ratio in cerebrospinal fluid.
▶Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjectsReviewRenan P. Souza et al.(2009)· Human Psychopharmacology: Clinical and Experimental
A systematic review of 98 studies investigating biological predictors of clozapine response in treatment-resistant schizophrenia. Of 70 genetic studies examining 379 variants, only three genetic variants have independently replicated findings: DRD3 Ser9Gly (rs6280), HTR2A His452Tyr, and GNB3 C825T (rs5442/rs5443). Non-genetic predictors include higher prefrontal cortical structural integrity and activity, and lower HVA:5-HIAA ratio in cerebrospinal fluid.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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