rs11030101

This is a coding sequence variant variant in the BDNF gene.

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Research that mentions this SNP (3)

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Val66Met polymorphism in the BDNF gene in children with bronchial asthma
AssociationN=497Milos Jesenak et al.(2015)· Pediatric Pulmonology

A case-control study of 248 asthmatic children and 249 healthy controls examining the BDNF Val66Met polymorphism (rs6265). The Met/Met variant was associated with increased asthma risk (OR=4.17, p=0.018), while the Val/Met genotype was protective (OR=0.69, p=0.045), especially in girls (OR=0.34, p=0.001). These findings suggest BDNF gene variations contribute to asthma susceptibility in children.

Traits studied:Allergic rhinitisAtopic dermatitisBronchial asthma
PubMedDOIMetascience Observatory
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No association of genetic variants in BDNF with major depression: A meta‐ and gene‐based analysis
Meta-analysisJoseph P. Gyekis et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Meta-analysis of 28 studies (range 38-7,173 participants) found no significant association between BDNF genetic variants and major depressive disorder. Val66Met (rs6265) showed OR=0.96 (95% CI: 0.89-1.05; P=0.402), and gene-based analysis of 17 total BDNF SNPs indicated no cumulative association with MDD (all P>0.21).

Traits studied:Major depressive disorder
PubMedDOIMetascience Observatory
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No association of brain‐derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese
ReviewTetsuya Ando et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This literature review examines the BDNF Val66Met polymorphism (rs6265) and its association with body weight fluctuations in psychiatric patients. The authors review evidence linking the Val66Met variant to weight changes across multiple psychiatric conditions including schizophrenia, eating disorders, bipolar disorder, major depressive disorder, OCD, and PTSD. The paper proposes the BDNF Val66Met polymorphism as a potential biomarker for monitoring body weight changes in psychiatric patients, noting that Met/Met genotype carriers show greater BMI increases particularly in schizophrenia and bipolar disorder.

Traits studied:Alzheimer's diseaseAnorexia nervosaBMIBipolar disorderBladder cancerBody weightBreast cancerBulimia nervosaCancerCardiovascular diseaseCoronary artery diseaseEating disordersGeneralized anxiety disorderMajor depressive disorderMetabolic syndromeMultiple sclerosisObesityObsessive-compulsive disorderParkinson's diseasePost-traumatic stress disorderSchizophreniaSubstance-related disordersType 2 diabetes
PubMedDOIMetascience Observatory

About BDNF

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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