BDNF
brain derived neurotrophic factor
Summary
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
Known Variants107 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7124442 | 11:27,677,041 | C/G | — | — |
| rs11030099 | 11:27,677,583 | C/A | 3 prime UTR variant | no classification for the single variant |
| rs11030100 | 11:27,677,586 | G/T | 3 prime UTR variant | — |
| rs41282918 | 11:27,678,780 | A/C | — | — |
| rs764951525 | 11:27,679,421 | T/C | — | uncertain significance |
| rs2538961114 | 11:27,679,453 | A/G | — | uncertain significance |
| rs2133780377 | 11:27,679,469 | C/T | — | uncertain significance |
| rs138287649 | 11:27,679,470 | G/A | — | likely benign |
| rs78572035 | 11:27,679,473 | C/T | — | benign |
| rs746089117 | 11:27,679,503 | A/G | — | likely benign |
| rs1852795747 | 11:27,679,555 | C/T | — | likely pathogenic |
| rs74975314 | 11:27,679,566 | G/A | — | benign |
| rs1554931219 | 11:27,679,610 | C/A | — | likely pathogenic |
| rs376008850 | 11:27,679,629 | G/A | — | likely benign |
| rs370102323 | 11:27,679,632 | C/T | — | uncertain significance |
| rs747058681 | 11:27,679,647 | A/G | — | likely benign |
| rs2353512 | 11:27,679,662 | T/C | — | benign |
| rs144235869 | 11:27,679,665 | C/T | — | likely benign |
| rs760274076 | 11:27,679,695 | G/A | — | likely benign |
| rs2538962988 | 11:27,679,746 | C/A | — | uncertain significance |
| rs765594245 | 11:27,679,747 | A/G | — | uncertain significance |
| rs755151584 | 11:27,679,789 | A/T | — | uncertain significance |
| rs148736382 | 11:27,679,791 | G/C | — | benign |
| rs935219250 | 11:27,679,803 | C/T | — | uncertain significance |
| rs150767807 | 11:27,679,839 | C/T | — | likely benign |
| rs78675155 | 11:27,679,854 | G/A | — | likely benign |
| rs2538963840 | 11:27,679,871 | C/A | — | uncertain significance |
| rs370382246 | 11:27,679,873 | T/C | — | uncertain significance |
| rs199638553 | 11:27,679,879 | C/T | — | uncertain significance |
| rs372937141 | 11:27,679,886 | T/C | — | uncertain significance |
| rs139352447 | 11:27,679,889 | G/C | — | likely benign |
| rs6265 | 11:27,679,916 | C/T | missense variant | benign |
| rs756240390 | 11:27,679,917 | G/A | — | likely benign |
| rs1852842557 | 11:27,679,928 | T/C | — | uncertain significance |
| rs2538964283 | 11:27,679,940 | A/G | — | uncertain significance |
| rs758274361 | 11:27,679,942 | G/T | — | uncertain significance |
| rs1488864054 | 11:27,679,948 | C/A | — | uncertain significance |
| rs1451603364 | 11:27,679,958 | C/T | — | uncertain significance |
| rs146354977 | 11:27,679,976 | C/T | — | uncertain significance |
| rs747701929 | 11:27,679,977 | G/A | — | likely benign |
| rs2538964679 | 11:27,679,984 | A/G | — | uncertain significance |
| rs763357890 | 11:27,679,999 | C/T | — | uncertain significance |
| rs2538964863 | 11:27,680,010 | G/A | — | likely benign |
| rs767681787 | 11:27,680,020 | C/T | — | uncertain significance |
| rs2538965118 | 11:27,680,040 | T/C | — | uncertain significance |
| rs764254110 | 11:27,680,042 | C/T | — | uncertain significance |
| rs750397219 | 11:27,680,063 | T/C | — | uncertain significance |
| rs8192466 | 11:27,680,107 | G/A | missense variant | pathogenic |
| rs11030101 | 11:27,680,744 | A/T | coding sequence variant | — |
| rs28722151 | 11:27,681,176 | C/G | — | benign |
| rs4030470 | 11:27,681,197 | C/T | — | benign |
| rs11819808 | 11:27,681,388 | C/T | — | benign |
| rs11030103 | 11:27,682,333 | A/G | intron variant | — |
| rs12273539 | 11:27,683,311 | C/T | intron variant | — |
| rs11030104 | 11:27,684,517 | A/G | intron variant | — |
| rs1808124 | 11:27,686,904 | T/C | intron variant | — |
| rs4517468 | 11:27,688,286 | A/C | — | — |
| rs11030105 | 11:27,690,566 | T/A | — | — |
| rs12291063 | 11:27,694,101 | T/C | intron variant | — |
| rs2049045 | 11:27,694,241 | G/C | intron variant | no classification for the single variant |
| rs11030107 | 11:27,694,835 | A/G | regulatory region variant | — |
| rs10767661 | 11:27,695,436 | C/G | — | benign |
| rs11030108 | 11:27,695,464 | G/A | — | benign |
| rs748698239 | 11:27,695,613 | G/T | — | uncertain significance |
| rs770444228 | 11:27,695,619 | A/C | — | uncertain significance |
| rs1045077557 | 11:27,695,628 | G/C | — | uncertain significance |
| rs551669106 | 11:27,695,665 | A/G | — | uncertain significance |
| rs1341834020 | 11:27,695,703 | T/C | — | likely benign |
| rs144776617 | 11:27,695,724 | G/A | — | likely benign |
| rs758930198 | 11:27,695,733 | T/C | — | likely benign |
| rs773531757 | 11:27,695,742 | C/T | — | likely benign |
| rs1564961192 | 11:27,695,765 | C/T | — | benign |
| rs369607397 | 11:27,695,785 | A/G | — | benign |
| rs10835210 | 11:27,695,910 | C/A | regulatory region variant | benign |
| rs16917234 | 11:27,698,374 | T/A | — | — |
| rs7103411 | 11:27,700,125 | C/T | regulatory region variant | — |
| rs7103873 | 11:27,700,317 | G/C | downstream gene variant | — |
| rs16917237 | 11:27,702,383 | G/T | downstream gene variant | — |
| rs35038967 | 11:27,703,480 | T/C | — | — |
| rs10835213 | 11:27,703,958 | A/T | downstream gene variant | — |
| rs34379767 | 11:27,704,209 | G/A | regulatory region variant | — |
| rs11030112 | 11:27,705,188 | G/A | intron variant | — |
| rs12801337 | 11:27,707,032 | G/A | intron variant | — |
| rs11500197 | 11:27,707,409 | G/A | intron variant | — |
| rs12575096 | 11:27,708,844 | A/C | — | — |
| rs7127507 | 11:27,714,884 | T/C | downstream gene variant | — |
| rs66866077 | 11:27,720,937 | T/C | — | benign |
| rs955482595 | 11:27,720,947 | C/G | — | uncertain significance |
| rs56164415 | 11:27,721,735 | G/A | downstream gene variant | uncertain significance |
| rs61888800 | 11:27,722,278 | G/C | — | — |
| rs7944119 | 11:27,722,298 | G/T | regulatory region variant | — |
| rs373949465 | 11:27,722,510 | A/G | — | likely benign |
| rs751074725 | 11:27,722,526 | A/C | — | uncertain significance |
| rs377250764 | 11:27,722,535 | C/T | — | uncertain significance |
| rs370909786 | 11:27,722,545 | C/G | — | likely benign |
| rs13306221 | 11:27,722,689 | C/T | regulatory region variant | — |
| rs56133711 | 11:27,723,334 | G/C | — | — |
| rs2049046 | 11:27,723,775 | T/A | upstream gene variant | — |
| rs988748 | 11:27,724,745 | C/G | upstream gene variant | — |
| rs10767664 | 11:27,725,986 | T/A | upstream gene variant | — |
Showing 100 of 107 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.