rs10835210

This is a regulatory region variant variant in the BDNF gene.

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ClinVar annotation

Benign★★★☆
2 submitters1 publication
View on ClinVar →
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Research that mentions this SNP (3)

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No association of genetic variants in BDNF with major depression: A meta‐ and gene‐based analysis
Meta-analysisJoseph P. Gyekis et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Meta-analysis of 28 studies (range 38-7,173 participants) found no significant association between BDNF genetic variants and major depressive disorder. Val66Met (rs6265) showed OR=0.96 (95% CI: 0.89-1.05; P=0.402), and gene-based analysis of 17 total BDNF SNPs indicated no cumulative association with MDD (all P>0.21).

Traits studied:Major depressive disorder
PubMedDOIMetascience Observatory
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Association of BDNF gene polymorphisms with schizophrenia and clinical symptoms in a Chinese population
AssociationN=709Wenjun Li et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Case-control study in 709 Han Chinese individuals (375 schizophrenia patients, 334 controls) examining BDNF gene polymorphisms. While no significant differences were found for single-locus analysis of rs6265 (Val66Met), rs12273539, and rs10835210, the haplotype ATC of rs6265-rs12273539-rs10835210 was significantly more frequent in patients than controls (P=0.027), and the ACA haplotype was significantly associated with negative symptom scores on the PANSS (χ²=5.789, P=0.016), suggesting BDNF gene variants may contribute to schizophrenia susceptibility and negative symptoms in Chinese populations.

Traits studied:Negative symptomsPositive symptomsPsychopathological symptomsSchizophrenia
PubMedDOIMetascience Observatory
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Associations of polymorphisms in the genes of FGFR2, FGF1, and RBFOX2 with breast cancer risk by estrogen/progesterone receptor status
AssociationN=2,416Yu‐Ling Cen et al.(2013)· Molecular Carcinogenesis

A hospital-based case-control study in rural and urban India (1,204 cases; 1,212 controls) examined genetic and lifestyle risk factors for breast cancer. Four SNPs in FGFR2 (rs1219648, rs2420946, rs2981575, rs2981582) showed positive associations with breast cancer (ORs 1.32-1.47). Additional SNPs in obesity and metabolic genes (rs374748 in FBN2, rs2922763 in HNF4G, rs2116830 in KCNMA1, rs11121832 in MTHFR, rs16886165 in MAP3K1, rs11594610 in TCF7L2, rs2274459 in MLN) were associated with increased breast cancer risk. Waist-to-hip ratio ≥0.95 showed strong association (OR 3.78; 95% CI 2.92-4.89), and women living first 20 years in rural areas showed protective effect (OR 0.77).

Traits studied:Breast cancerBreast cancer riskER+/PR+ breast cancerER/PR negative breast cancerTriple negative breast cancer
PubMedDOIMetascience Observatory

About BDNF

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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