rs6265

This study evaluated the use of polygenic scores (PGS) based on 10 top SNPs from European GWAS meta-analysis of antisocial behavior to predict liability to severe criminal behavior (homicide) in a Russian cohort of 227 offenders and 254 controls. A PGS based on rs993137 (CADM2), rs458806 (REV3L), rs11720703 (FOXP1), and rs1476535 (FOXP2) explained 1.5% of variance in liability to antisocial behavior, while the combined genetic model with social factors (traumatic brain injury, chronic disease, tobacco smoking) explained up to 21.2% of variance (p = 2 × 10⁻¹³), demonstrating that social factors have substantially greater predictive impact than genetic variants alone.

A literature review of 70 studies examining single nucleotide polymorphisms (SNPs) associated with obesity in Mexican populations published 2011-2021. The authors identified SNPs with differential behavior in Mexican compared to Caucasian populations, including rs17782313 (MC4R), rs6548238 (TMEM18), rs6265 (BDNF), rs7498665 (SH2B1), and notably rs6232 (PCSK1) associated with early-onset obesity in Mexican youth. The review emphasizes ethnicity-dependent genetic effects on BMI heritability (40-70%) and highlights genes involved in cholesterol metabolism and adipokine signaling pathways.

This population-based case-control study examined the association between BDNF rs6265 polymorphism and smoking cessation behavior in 20,584 Taiwanese adults from the Taiwan Biobank. Contrary to previous studies suggesting association between rs6265 and smoking behavior, this study found no significant association between the polymorphism (TT, TC, CC genotypes) and smoking cessation (p = 0.8753). Instead, sociodemographic and lifestyle factors (age, education, marital status, drinking, exercise, BMI) were significant predictors of smoking cessation, with males (OR 0.750), drinkers (OR 0.707), and underweight individuals (OR 0.597) less likely to quit smoking.

A prospective pharmacogenetic study of 220 treatment-resistant depression (TRD) patients examined 50 tag SNPs in 14 neuroplasticity and second messenger pathway genes for association with antidepressant response. Key findings included replication of ZNF804A rs7603001 with venlafaxine response (OR=2.51), CREB1 rs2254137 with remission, CHL1 rs2133402 with lower TRD risk, and MAPK1 rs6928 with all phenotypes (p=0.0006 after Bonferroni). Pathway analysis in STAR*D (n=1846) identified protein processing in the endoplasmic reticulum pathway as a potential mechanism of MAPK1 involvement.

This international doctoral thesis examined gene-physical activity interactions in fibromyalgia through six studies analyzing 64 SNPs across 34 candidate genes in Spanish women. The case-control study (314 fibromyalgia cases vs. 112 controls) identified associations of rs841 (GCH1), rs1799971 (OPRM1), and rs2097903 (COMT) with fibromyalgia susceptibility (p=0.04, p=0.02, and p=0.04 respectively). Cross-sectional studies (n=274-276 fibromyalgia patients) found that SCN9A rs4453709 and other genetic polymorphisms interacted with physical activity to influence pain, fatigue, and resilience outcomes.

This review examines neurogenetic and neuropharmacological correlates of opioid use disorder (OUD) with emphasis on ancestry-specific genetic risk profiles. The paper identifies multiple genes involved in the reward pathway (DRD2, DRD3, DRD4, OPRM1, OPRK1, OPRD1, BDNF, NRXN3, COMT, SLC6A4, KCNC1, KCNG2) and their variants associated with OUD susceptibility and treatment response across different ethnic populations, highlighting critical research disparities where African Americans and Hispanics have been underrepresented in genetic association studies.

A genetic association study in 252 healthy Japanese controls examining SNP polymorphisms in BDNF and NTRK2 genes and their association with stress-coping strategies, ego aptitude, and social adaptation. BDNF rs6265 (Val/Met) showed significant associations with emotion-focused coping, seeking social support, self-control, and distancing. Five NTRK2 SNPs (rs11140800, rs1187286, rs1867283, rs1147198, rs10868235) demonstrated significant associations with cognitive strategies, problem-solving, and multiple ego-related factors.

A case-control study of 248 asthmatic children and 249 healthy controls examining the BDNF Val66Met polymorphism (rs6265). The Met/Met variant was associated with increased asthma risk (OR=4.17, p=0.018), while the Val/Met genotype was protective (OR=0.69, p=0.045), especially in girls (OR=0.34, p=0.001). These findings suggest BDNF gene variations contribute to asthma susceptibility in children.

This molecular imaging genetics study investigated 52 healthy Caucasian volunteers to determine whether the common COMT gene polymorphism rs4680 (VAL158MET) affects serotonin-1A (5-HT1A) receptor binding. Using PET imaging with [carbonyl-11C]WAY-100635, the researchers found that homozygote GG carriers showed significantly higher 5-HT1A receptor binding potential compared to A carriers (AA+AG) in multiple brain regions including the posterior cingulate cortex (F(2,49)=17.7, p=0.05, FWE corrected), orbitofrontal cortex, anterior cingulate cortex, insula, amygdala, and hippocampus. The effect sizes were large (Cohen's d=1.43 for AA vs. GG), supporting the hypothesis that COMT may modulate serotonergic neurotransmission relevant to mood and anxiety disorders.

This review examines the genetic and epigenetic basis of Tourette Syndrome (TS), a neurodevelopmental disorder with high heritability (0.45-0.77). The paper reviews candidate gene associations including variants in SLITRK1 (rs9593835, rs9546538, rs9531520), DRD2/ANKK1 (rs1800497), ADORA1/ADORA2A (rs2228079, rs5751876), and other dopaminergic genes, along with a large GWAS in 1285 cases and 4964 controls highlighting rs7868992 in COL27A1. The review proposes that epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) may link genetic susceptibility with environmental factors in TS pathogenesis.

This candidate gene association study examined 82 participants (38 with major depressive disorder, 44 healthy controls) to investigate how the BDNF Val66Met polymorphism (rs6265) interacts with childhood adversity to influence hippocampal subfield volumes. Patients with MDD had significantly smaller CA4/DG and CA2/3 volumes compared to healthy controls. Critically, Met-allele carriers showed a significant interaction with childhood adversity: Met carriers with childhood adversity had smaller CA4/DG and CA2/3 volumes, while Met carriers without adversity had larger volumes than Val/Val homozygotes.

Association study of 55 SNPs in 887 Hungarian adults examining genetic predisposition to aggression measured by the Buss-Perry Aggression Questionnaire. The HTR2A rs7322347 intronic variant showed significant association with aggression after Bonferroni correction (p = 0.0007), with carriers of the minor A allele showing lower aggression levels. The DRD4 rs916455 variant also showed nominal significance (p = 0.0275) but did not survive multiple testing correction.

Meta-analysis of 28 studies (range 38-7,173 participants) found no significant association between BDNF genetic variants and major depressive disorder. Val66Met (rs6265) showed OR=0.96 (95% CI: 0.89-1.05; P=0.402), and gene-based analysis of 17 total BDNF SNPs indicated no cumulative association with MDD (all P>0.21).

This dissertation examined the influence of ovarian steroids on hippocampal memory function and morphology, with Experiment 2 investigating the association between a CYP19A1 SNP (rs700518) predicting estrogen levels and hippocampal gray matter volume in healthy young men (N=161 for structural imaging, N=157 for behavioral testing). The rs700518 polymorphism showed significant associations with posterior hippocampal volume (Cohort A: left Z=3.73 p=.017, right Z=3.76 p=.015; Cohort B: left Z=3.75 p=.016, right Z=4.40 p=.001), where AA genotype carriers (high E2 disposition) had greater hippocampal gray matter than AG/GG carriers (low E2 disposition). However, behavioral memory tasks (emotional memory, spatial learning, verbal source memory) showed no significant genotype differences.

Genome-wide association study examining common variants near BDNF (rs6265, rs925946) and SH2B1 (rs7498665) in relation to snacking behavior across three European cohorts (French obese children, Swiss obese, D.E.S.I.R.). The study reports nominal evidence of association, with rs925946 in BDNF showing OR=1.21 (p=5.03×10⁻³) in the D.E.S.I.R. cohort and rs7498665 in SH2B1 showing OR=1.17 (p=9.57×10⁻³) in the Swiss cohort.

This study examined 8 adult obesity-susceptibility loci in 7,225 children aged 2-18 years using quantile regression to assess whether genetic effects on BMI are uniform across the BMI distribution. The authors found that obesity risk alleles (FTO rs3751812, MC4R rs12970134, TMEM18 rs2867125, BDNF rs6265, SEC16B rs10913469, GNPDA2 rs13130484, NRXN3 rs10146997, and TNNI3K rs1514175) were more strongly associated with BMI increases at the upper tail of the distribution (85th-95th percentiles, β=0.06-0.11, p<10^-6) compared to the lower tail, suggesting that standard linear regression approaches may underestimate genetic effects on childhood obesity.

This comprehensive literature review examines the role of single-nucleotide polymorphisms (SNPs) and genetic variants in dystonia susceptibility, reviewing 43 published studies (2001-2017) across 29 genes. Key findings include associations of TOR1A variants (rs1182, rs1801968, rs35153737) with focal dystonia, BDNF rs6265 (Val66Met) with cervical dystonia and blepharospasm, and preliminary GWAS-identified variants in ARSG (rs11655081, rs61999318) and NALCN with dystonia risk. The review concludes that genetic factors confer dystonia susceptibility through multiple pathways, though many associations require validation in larger cohorts.

A hospital-based case-control study in rural and urban India (1,204 cases; 1,212 controls) examined genetic and lifestyle risk factors for breast cancer. Four SNPs in FGFR2 (rs1219648, rs2420946, rs2981575, rs2981582) showed positive associations with breast cancer (ORs 1.32-1.47). Additional SNPs in obesity and metabolic genes (rs374748 in FBN2, rs2922763 in HNF4G, rs2116830 in KCNMA1, rs11121832 in MTHFR, rs16886165 in MAP3K1, rs11594610 in TCF7L2, rs2274459 in MLN) were associated with increased breast cancer risk. Waist-to-hip ratio ≥0.95 showed strong association (OR 3.78; 95% CI 2.92-4.89), and women living first 20 years in rural areas showed protective effect (OR 0.77).

This genome-wide association study identified rs6265 (Val66Met) in the BDNF gene as a phosSNP (phosphorylation-related SNP) associated with bone mineral density (BMD) in three independent populations (~5,000 subjects total). Individuals carrying the AA genotype had significantly lower hip BMD than GA/GG carriers. Functional studies demonstrated that rs6265 regulates BDNF protein phosphorylation at residue T62 and affects osteoblast differentiation through modulation of genes OPN, BMP2, and ALP.

The Acute to Chronic Pain Signatures (A2CPS) is a multicenter prospective observational study protocol designed to identify biomarkers and biosignatures that predict development of chronic postsurgical pain. The study will recruit 3,600 patients undergoing knee arthroplasty or thoracic surgery and collect comprehensive biopsychosocial assessments including genetic variants via the Infinium Global Screening Array (GSA BeadChip with >650,000 markers), brain imaging, quantitative sensory testing, proteomic/metabolomic analyses, and patient-reported outcomes at baseline, 6 weeks, 3 months, and 6 months to identify predictive biomarkers for the transition from acute to chronic pain.

This study examined how aging and the KIBRA rs17070145 polymorphism affect spatial memory processes in a virtual navigation task (N=152). Older adults showed better learning with landmark-related spatial information compared to younger adults, who relied more on boundary information. Among older adults, T-allele carriers of KIBRA rs17070145 demonstrated significantly better spatial learning performance compared to C homozygotes (mean cumulative distance error: 2995 vm vs 3856 vm, P=0.003), but this effect was not observed in younger adults.

Case-control study in 709 Han Chinese individuals (375 schizophrenia patients, 334 controls) examining BDNF gene polymorphisms. While no significant differences were found for single-locus analysis of rs6265 (Val66Met), rs12273539, and rs10835210, the haplotype ATC of rs6265-rs12273539-rs10835210 was significantly more frequent in patients than controls (P=0.027), and the ACA haplotype was significantly associated with negative symptom scores on the PANSS (χ²=5.789, P=0.016), suggesting BDNF gene variants may contribute to schizophrenia susceptibility and negative symptoms in Chinese populations.

BDNF Val66Met (rs6265) genotype interacts with sex to influence bimanual motor control in healthy humans. Seventy-six participants performed a bimanual motor control task (Preilowski's task) involving line drawing at various angles. The study found a significant genotype-by-sex-by-angle interaction (F(1,65)=4.01, P=0.028), with Val-homozygous females performing significantly worse on difficult angles compared to Met-carrier females (P=0.044), an effect absent in males.

This association study examined the BDNF Val66Met polymorphism (rs6265) in 158 subjects (66 schizophrenic, 45 bipolar, 47 healthy controls) using MRI and MR spectroscopy. Met/met homozygotes showed significantly lower NAA/Cre (−21.1%, F(1,52)=4.80, p=0.033) and Glu+Gln/Cre ratios (−46.0%, F(1,52)=6.20, p=0.016) in the left hippocampus compared to val/val homozygotes, providing in vivo evidence for BDNF effects on glutamate system function.

This literature review examines the BDNF Val66Met polymorphism (rs6265) and its association with body weight fluctuations in psychiatric patients. The authors review evidence linking the Val66Met variant to weight changes across multiple psychiatric conditions including schizophrenia, eating disorders, bipolar disorder, major depressive disorder, OCD, and PTSD. The paper proposes the BDNF Val66Met polymorphism as a potential biomarker for monitoring body weight changes in psychiatric patients, noting that Met/Met genotype carriers show greater BMI increases particularly in schizophrenia and bipolar disorder.

This prospective study examined the association between BDNF Val66Met gene polymorphism (rs6265) and antidepressant response in 57 Han Chinese patients with first-episode late-life depression. After 8 weeks of treatment with escitalopram or sertraline, serum BDNF levels increased significantly (p=0.026). Binary logistic regression identified male sex (OR=10.094, p=0.007) and the Val/Val genotype (OR=6.559, p=0.003) as independent predictors of treatment efficacy. The study found that male patients carrying the Val/Val genotype responded better to conventional antidepressants, though no significant correlation was found between BDNF level changes and treatment response.

Meta-analysis of five case-control studies (523 geriatric depression cases, 1,220 controls) found that BDNF Val66Met Met allele carriers had significantly increased risk for geriatric depression (P=0.004, OR=1.48, 95% CI=1.13-1.93). The Met allele, associated with reduced BDNF activity and altered hippocampal function, appears to confer greater depression risk in elderly populations than in younger adults.

This systematic review and validation study examined psychosis-associated SNPs and their effects on brain volumetry in 113 subjects (schizophrenia, bipolar disorder, at-risk mental state, and healthy controls). Of 25 studies identified in the systematic review implicating 7 SNPs in 5 genes, the authors tested these variants using voxel-based morphometry. They found FWER-corrected associations for CACNA1C rs769087-A with larger bilateral hippocampus and thalamus white matter (p = 0.026 and p = 0.036) and with larger superior frontal gyrus volume. Higher replication concordance was found for CACNA1C, ZNF804A, and BDNF variants, supporting their involvement in psychosis and brain structure.

Genome-wide association study of six eating disorder-related phenotypes (Drive for Thinness, Body Dissatisfaction, Bulimia, Weight Fluctuation, Breakfast Skipping, and Childhood Obsessive-Compulsive traits) across 2,698-2,967 individuals from TwinsUK discovery and two independent European replication cohorts. Meta-analysis identified eight genetic variants with suggestive evidence of association (P < 10^-5), including rs7624327 near CCNL1 (P=3.34E-06, OR=1.13 for Bulimia), rs1898111 in SEMA6D (P=7.66E-06, OR=0.872 for OCPD), and rs6894268 in RUFY1 (P=2.38E-06 for Body Dissatisfaction), but no signals reached genome-wide significance threshold (P < 5×10^-8).

Study of 152 adults (77 older, 75 younger) examined effects of KIBRA SNP rs17070145 on spatial navigation in virtual reality. Older adults performed worse overall, and among older adults, T-allele carriers showed better spatial learning performance than C/C homozygotes (mean error 2995 vm vs 3856 vm, p=0.003). Older adults relied more on landmark-based navigation while younger adults relied more on boundary-based cues.

This multicenter cross-sectional study examined 98 multiple sclerosis patients to assess the role of the BDNF Val66Met polymorphism (rs6265) on cognitive and motor disability. The Met allele was found to be protective against cognitive impairment, with Met carriers showing fewer failed neuropsychological tests (β = -1.1, p = 0.027) and better performance on spatial recall tests. Higher EDSS disability scores were associated with progressive disease course but showed only marginal association with the BDNF polymorphism.

This comprehensive review examines the genomics of schizophrenia and pharmacogenomics of antipsychotic drugs, synthesizing evidence on over 200 genes associated with psychotic disorders. The authors discuss five categories of genes relevant to antipsychotic response: disease-associated genes, mechanism-of-action genes, drug metabolism genes (particularly CYP2D6, CYP2C19, CYP2C9, CYP3A4), drug transporter genes, and pleiotropic genes. The review details pharmacogenomic profiles of 20+ antipsychotic drugs and demonstrates significant ethnic and interindividual variation in drug metabolism phenotypes, with examples including CYP2D6 extensive metabolizers (55.71% of population), intermediate metabolizers (34.7%), poor metabolizers (2.28%), and ultra-rapid metabolizers (7.31%).

This PhD thesis comprehensively explores associations between the CHRNA5-A3-B4 nicotinic acetylcholine receptor gene cluster and smoking-related behaviors. Using systematic review/meta-analysis, genetic epidemiology, laboratory-based techniques, and genome-wide meta-analysis, the study found compelling evidence for a small, robust association between rs16969968/rs1051730 and daily cigarette consumption with a per-allele effect of approximately one cigarette per day (beta≈1.0). A genome-wide meta-analysis of cotinine levels in 2,139 current smokers identified multiple variants in the CHRNA5 region strongly associated with tobacco exposure. However, no association was observed with smoking initiation in a prospectively-assessed cohort.

Replication study of 14 obesity-associated SNPs from 13 loci in 18,264 Japanese participants, confirming associations at 11 loci including TMEM18 (rs4854344, p=7.1×10⁻⁷ for BMI), FTO, MC4R, BDNF, and others. Six obesity variants also associated with type 2 diabetes after BMI adjustment (OR 1.05-1.17), with FTO showing strong meta-analyzed association in East Asians (OR 1.13, p=7.8×10⁻¹⁰).

Meta-analysis of the BDNF p.Val66Met polymorphism (rs6265) across four European populations including 1,445 adult ADHD patients and 2,247 controls found no significant association between the variant and adult ADHD (P = 0.86; OR = 0.99, 95% CI: 0.86-1.13). The analysis also found no significant effects when stratified by gender, ADHD subtype, or comorbidity with mood disorders.

This systematic review of 98 studies examined biological predictors of clozapine response in treatment-resistant schizophrenia patients. Of 379 different gene variants investigated across 70 genetic studies, only three variants (DRD3 Ser9Gly rs6280, HTR2A His452Tyr, and GNB3 C825T) achieved independent replication. Non-genetic predictors included higher prefrontal cortical volumes and lower HVA:5-HIAA ratio in cerebrospinal fluid.

Meta-analysis of 21 case-control studies (7,219 bipolar disorder patients vs 9,832 controls) examining the BDNF Val66Met polymorphism (rs6265, G196A) and bipolar disorder susceptibility. Overall, no significant association was found (pooled OR=1.03, 95% CI 0.98-1.08), though a trend emerged in Caucasians (OR=1.08, P=0.05) and the Val allele showed a protective effect for bipolar II disorder (OR=0.88, P=0.03).

This association study examined the BDNF Val66Met polymorphism (rs6265) in 301 bipolar disorder patients and 484 healthy controls from India. The Val(G) allele was significantly more frequent in BD patients (OR=1.47, 95% CI=1.11-1.96, χ²=7.08, p=0.008), consistent with European populations. However, no significant association was found between the Val66Met polymorphism and lithium treatment response (N=190 BD subjects).

Meta-analytic review of candidate gene studies for childhood ADHD examining 19 genes. Significant associations identified for DAT1 (3' UTR VNTR: OR=1.12, p=0.028; rs27072: OR=1.20, p=0.006), DRD4 (exon 3 VNTR: OR=1.33, p=0.00007; rs1800955: OR=1.21, p=0.007), DRD5, 5HTT, HTR1B (rs6296: OR=1.11, p=0.010), and SNAP25 (rs3746544: OR=1.15, p=0.030).

A targeted sequencing study of 115 patients with bipolar disorder and depression identified genetic variants in NRG1, PIP4K2A, and HTR2C associated with treatment response and disease severity. The allele C of rs35641374 (NRG1) was associated with longer intervals between depressive episodes (p=4.37e-07), while the allele C of rs10508649 (PIP4K2A) was associated with longer intervals between manic/mixed episodes (p=0.000309) and treatment resistance assessed by CGI-I scale (p=0.000943). The allele A of rs2248440 (HTR2C) was associated with higher depression severity (p=0.003).

This targeted sequencing association study of 115 psychiatric patients and 34 controls identifies NRG1, PIP4K2A, and HTR2C as candidate biomarker genes for antidepressant treatment response and mood disorder recurrence. Key findings include rs35641374 (NRG1) associated with longer time to depressive recurrence in bipolar disorder (p=4.37e-07), rs61731109 and rs10508649 (PIP4K2A) associated with antidepressant non-response (p=0.00111 and p=0.000943), and rs2248440 (HTR2C) associated with higher depression severity (p=0.003).

This study investigated how the BDNF Val66Met polymorphism (rs6265) modulates reward circuitry responses to emotional facial expressions in 29 healthy adults. BDNF V66M genotype explained approximately 30% of the variance in fMRI activation in the orbitofrontal cortex, amygdala, and hippocampus. Val/Val individuals preferentially sought exposure to happy faces and showed stronger activation to aversive stimuli (angry, fearful, sad), while Val/Met carriers showed more balanced responses across emotional expressions.

A systematic review of 98 studies investigating biological predictors of clozapine response in treatment-resistant schizophrenia. Of 70 genetic studies examining 379 variants, only three genetic variants have independently replicated findings: DRD3 Ser9Gly (rs6280), HTR2A His452Tyr, and GNB3 C825T (rs5442/rs5443). Non-genetic predictors include higher prefrontal cortical structural integrity and activity, and lower HVA:5-HIAA ratio in cerebrospinal fluid.

This study extended genetic linkage analysis to 3D diffusion tensor images (DTI) in 258 twins and siblings to map single gene effects on brain fiber architecture. The BDNF Val66Met polymorphism (rs6265) significantly influenced fractional anisotropy (FA) in the posterior cingulate gyrus, accounting for 90-95% of local FA variance. Raw FA images without smoothing provided greatest sensitivity for detecting gene effects when corrected for multiple comparisons using false discovery rate procedures.

This comprehensive review synthesizes genomic and pharmacogenomic research in schizophrenia, discussing over 200 candidate genes associated with psychotic disorders, genetic mechanisms including copy number variants and microRNA alterations, and pharmacogenomic factors affecting antipsychotic efficacy and safety. Key genes covered include dopamine receptors (DRD1-5), dysbindin (DTNBP1), DISC1, neurotrophic factors, and metabolic enzymes such as CYP2D6, CYP3A4, and COMT, with emphasis on genotype-phenotype correlations in antipsychotic response and side effects.

This study examined interactive effects of COMT (rs4680, Val158Met) and BDNF (rs6265, Val66Met) polymorphisms on working memory performance and resting-state brain activity in 417 healthy Chinese adults (298 with fMRI data). Significant gene-gene interactions were found for working memory performance and regional homogeneity across multiple frontal brain regions, with COMT-VV/BDNF-VV genotypes showing higher working memory performance and lower frontal ReHo.

Genetic association study of BDNF variants and depression combining two cohort studies (BWHHS, n=3,548; ALSPAC, n=6,838) with meta-analysis of nine publications. The Val66Met variant (rs6265) showed no strong evidence of association with depression (meta-analysis OR=1.06, 95% CI: 0.89-1.26 for MM vs VV genotypes; OR=0.97, 95% CI: 0.89-1.05 for MV vs VV). The C270T polymorphism also showed no evidence of association. Findings suggest BDNF genotype does not exert major influence on development of depression.

PhD thesis investigating genome-wide transcriptional and methylomic consequences of a balanced t(1;11) chromosomal translocation linked to schizophrenia, bipolar disorder, and major depression. DNA methylation profiling in 41 family members identified differential methylation at translocation breakpoint regions (chromosomes 1 and 11) and genes related to psychiatric disorders and neurodevelopment. Gene expression analysis in lymphoblastoid cells (13 family members) and iPSC-derived neurons (6 individuals) identified SORL1 as a candidate gene, with follow-up functional analysis in Disc1 L100P mouse model and epistasis studies in human GWAS data.

A candidate gene association study examined six SNPs in neurotrophic factor genes (NTF3, NTRK2, NTRK3, BDNF, p75NTR) for association with adult ADHD scores in 143 high-risk males from a forensic psychiatric unit. While no SNPs showed significant association after Bonferroni correction, rs6332 in NTF3 exon III showed a trend toward association with increased ADHD scores (P=0.05 for WURS-k; P=0.03 for Wender-Reimherr interview), suggesting the A-allele may be a potential risk factor.

This case-control study of 42 African-American subjects with DSM-III-R schizophrenia examines the BDNF Val66Met variant (rs6265) and its association with age of onset. The study found a significant relationship between BDNF Val66Met genotype and both age of first psychiatric hospitalization (P=0.023) and first schizophrenia symptoms (P=0.006), with Val/Val homozygotes showing later onset than Val/Met heterozygotes.