rs66866077

This variant is located in the BDNF gene.

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ClinVar annotation

Benign★★★☆
2 submitters2 publications

not specified; not provided

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Research that mentions this SNP (2)

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Association of GSK3β Polymorphisms With Brain Structural Changes in Major Depressive Disorder
AssociationN=149Becky Inkster et al.(2009)· Archives of General Psychiatry

A targeted sequencing study of 115 patients with bipolar disorder and depression identified genetic variants in NRG1, PIP4K2A, and HTR2C associated with treatment response and disease severity. The allele C of rs35641374 (NRG1) was associated with longer intervals between depressive episodes (p=4.37e-07), while the allele C of rs10508649 (PIP4K2A) was associated with longer intervals between manic/mixed episodes (p=0.000309) and treatment resistance assessed by CGI-I scale (p=0.000943). The allele A of rs2248440 (HTR2C) was associated with higher depression severity (p=0.003).

Traits studied:Antidepressant treatment responseBipolar affective disorderDepression severityDepressive episodeRecurrent depressive disorderTime to recurrence of depressive episodesTime to recurrence of manic/mixed episodes
PubMedDOIMetascience Observatory
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Focus on HTR2C: A possible suggestion for genetic studies of complex disorders
AssociationN=149Antonio Drago et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This targeted sequencing association study of 115 psychiatric patients and 34 controls identifies NRG1, PIP4K2A, and HTR2C as candidate biomarker genes for antidepressant treatment response and mood disorder recurrence. Key findings include rs35641374 (NRG1) associated with longer time to depressive recurrence in bipolar disorder (p=4.37e-07), rs61731109 and rs10508649 (PIP4K2A) associated with antidepressant non-response (p=0.00111 and p=0.000943), and rs2248440 (HTR2C) associated with higher depression severity (p=0.003).

Traits studied:Antidepressant treatment responseBipolar I disorderBipolar II disorderBipolar disorderDepression severityMajor depressive disorderRemission statusTime to recurrence of depressive episodeTime to recurrence of manic/mixed episode
PubMedDOIMetascience Observatory

About BDNF

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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