rs7103873
This is a downstream gene variant variant in the BDNF gene.
▶Research that mentions this SNP (1)
▶No association of genetic variants in BDNF with major depression: A meta‐ and gene‐based analysisMeta-analysisJoseph P. Gyekis et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Meta-analysis of 28 studies (range 38-7,173 participants) found no significant association between BDNF genetic variants and major depressive disorder. Val66Met (rs6265) showed OR=0.96 (95% CI: 0.89-1.05; P=0.402), and gene-based analysis of 17 total BDNF SNPs indicated no cumulative association with MDD (all P>0.21).
About BDNF
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
View all BDNF variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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