rs2049045

Association study of 55 SNPs in 887 Hungarian adults examining genetic predisposition to aggression measured by the Buss-Perry Aggression Questionnaire. The HTR2A rs7322347 intronic variant showed significant association with aggression after Bonferroni correction (p = 0.0007), with carriers of the minor A allele showing lower aggression levels. The DRD4 rs916455 variant also showed nominal significance (p = 0.0275) but did not survive multiple testing correction.

Association study of BDNF and LIN-7 genes with adult ADHD using 80 family trios and 121 case-control pairs (201 total probands). Five BDNF SNPs and two LIN-7 SNPs were tested; the functional Val66Met polymorphism (rs6265) and BDNF_2 (rs11030104) showed significant associations after multiple testing correction with odds ratios of 1.65 (p=0.0096) and 1.66 (p=0.0085) respectively. LIN-7_1 (rs10835188) was also significantly associated with adult ADHD.

This study analyzed genotype-expression interactions for BDNF across five human brain regions using GTEx data from 300 subjects (985 tissue samples). At FDR < 0.1, 61 SNPs in cerebellum, 55 in cortex, 48 in nucleus accumbens, 47 in caudate, and 58 in cerebellar hemisphere were associated with BDNF expression. Thirty SNPs in two haplotype blocks were shared across all five regions, including rs6265 (Val66Met), rs16917204, rs11030104, and rs6484320, which have been previously associated with psychiatric disorders including depression, bipolar disorder, schizophrenia, OCD, epilepsy, and addiction.