rs551669106

This variant is located in the BDNF gene.

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ClinVar annotation

Uncertain Significance
1 submitter

BDNF-related disorder

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Research that mentions this SNP (1)

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No association of brain‐derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese
ReviewTetsuya Ando et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This literature review examines the BDNF Val66Met polymorphism (rs6265) and its association with body weight fluctuations in psychiatric patients. The authors review evidence linking the Val66Met variant to weight changes across multiple psychiatric conditions including schizophrenia, eating disorders, bipolar disorder, major depressive disorder, OCD, and PTSD. The paper proposes the BDNF Val66Met polymorphism as a potential biomarker for monitoring body weight changes in psychiatric patients, noting that Met/Met genotype carriers show greater BMI increases particularly in schizophrenia and bipolar disorder.

Traits studied:Alzheimer's diseaseAnorexia nervosaBMIBipolar disorderBladder cancerBody weightBreast cancerBulimia nervosaCancerCardiovascular diseaseCoronary artery diseaseEating disordersGeneralized anxiety disorderMajor depressive disorderMetabolic syndromeMultiple sclerosisObesityObsessive-compulsive disorderParkinson's diseasePost-traumatic stress disorderSchizophreniaSubstance-related disordersType 2 diabetes
PubMedDOIMetascience Observatory

About BDNF

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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