rs11037575

This variant is located in the HSD17B12 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroblastoma

Diskin SJ et al. “Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.” Nature Genetics 44(10):1126-30 (2012)

Allele C

OR 1.23

p 5.0e-8

N 6,303

Large GWAS

multi-ancestry

About HSD17B12

This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]

View all HSD17B12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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