rs11057353
This variant is located in the DNAH10 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
adiponectin measurement
Spracklen CN et al. “Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.” American Journal of Human Genetics 105(1):15-28 (2019)
Allele C
OR —
β 0.053
p 1.0e-19
N 67,739
Large GWAS
multi-ancestry
BMI-adjusted waist-hip ratio
Emdin CA et al. “DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.” Diabetes 68(1):226-234 (2019)
Allele T
OR 0.02
p 3.0e-17
N 405,569
Large GWAS
European
Justice AE et al. “Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.” Nature Genetics 51(3):452-469 (2019)
Allele T
OR 0.02
p 2.0e-16
N 344,369
Large GWAS
multi-ancestry
▶ClinVar annotation
About DNAH10
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
View all DNAH10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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