rs1105770

This is a 3 prime utr variant variant in the TNFAIP8 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele T

OR —

p 6.0e-9

N 2,535,601

Large GWAS

multi-ancestry

About TNFAIP8

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all TNFAIP8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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