rs11067228

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

prostate specific antigen amount

Hoffmann TJ et al. “Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.” Nature Genetics 57(2):334-344 (2025)
Allele A
OR 0.04
p 6.0e-96
N 392,522
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.05
p 3.0e-62
N 254,502
Major Consortium StudyLarge GWAS
European
Hoffmann TJ et al. “Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.” Nature Communications 8:14248 (2017)
Allele A
OR 0.04
p 1.0e-14
N 28,503
Large GWAS
multi-ancestry
Gudmundsson J et al. “Genetic correction of PSA values using sequence variants associated with PSA levels.” Science Translational Medicine 2(62):62ra92 (2010)
Allele A
OR 8.30
p 2.0e-11
N 7,538
Large GWAS
European

heel bone mineral density

Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele A
OR 0.02
p 2.0e-17
N 426,824
Large GWAS
European
Kemp JP et al. “Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis.” Nature Genetics 49(10):1468-1475 (2017)
Allele A
OR 0.02
p 2.0e-11
N 142,487
Large GWAS
European

prostate carcinoma

Wang A et al. “Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.” Nature Genetics 55(12):2065-2074 (2023)
Allele A
OR 1.03
p 1.0e-11
N 944,762
Large GWAS
multi-ancestry

grip strength measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.01
p 5.0e-9
N 404,112
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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