rs11073058

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

axial length measurement

Cheng CY et al. “Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.” American Journal of Human Genetics 93(2):264-77 (2013)
Allele T
OR 0.07
p 4.0e-11
N 12,531
Large GWAS
multi-ancestry
Miyake M et al. “Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.” Nature Communications 6:6689 (2015)
Allele T
OR 0.09
p 2.0e-8
N 3,248
Large GWAS
East Asian
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Research that mentions this SNP (1)

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Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium
Meta-analysisN=55,177Verhoeven VJ et al.(2012)· Human Genetics

This large-scale international meta-analysis of 55,177 individuals from the CREAM consortium confirms the association of chromosome 15q14 locus with myopia. The top SNP rs634990 showed highly significant association (P = 9.20 × 10⁻²³), with homozygous risk allele carriers having OR 1.88 (95% CI 1.64-2.16) for myopia versus hyperopia, and heterozygous carriers having OR 1.33 (95% CI 1.19-1.49). All 14 SNPs at 15q14 replicated significantly in both Caucasians (P = 3.87 × 10⁻¹²) and Asians (P = 2.21 × 10⁻³), while SNPs at 15q25 did not replicate (P = 5.81 × 10⁻²).

Traits studied:High hyperopiaHigh myopiaMyopiaRefractive errorSpherical equivalent
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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