rs11078697

This variant is located in the SENP3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sex hormone-binding globulin measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.26

p 2.0e-128

N 322,484

Major Consortium StudyLarge GWAS

multi-ancestry

testosterone measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)

Allele T

OR 0.12

p 9.0e-27

N 322,594

Major Consortium StudyLarge GWAS

multi-ancestry

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Research that mentions this SNP (1)

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Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers

AssociationN=3,495Chen Yang et al.(2012)· Immunogenetics

Two-stage genome-wide association study in 3,495 healthy Chinese men identified TNFSF13 as a susceptibility locus for serum IgA levels. The lead variant rs3803800 showed significant association (P = 6.26×10⁻⁸ in stage 1, combined P = 2.97×10⁻⁷), with markedly stronger association in smokers (P = 3.96×10⁻⁷) compared to nonsmokers (P = 2.28×10⁻¹), suggesting smoking modulates the genetic effect on IgA levels.

Traits studied:Serum IgA level

PubMed DOI Metascience Observatory

About SENP3

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]