rs11111278

This is a intron variant variant in the IGF1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cerebellar volume measurement

Tissink E et al. “Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health.” Communications Biology 5(1):710 (2022)

Allele G

OR 1112.20

p 2.0e-24

N 27,486

Large GWAS

European

Moberget T et al. “The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.” Communications Biology 9(1) (2026)

Allele G

OR —

p 2.0e-21

N 27,302

Large GWAS

European

brain volume

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)

Allele G

OR 0.10

p 2.0e-16

N 21,282

Major Consortium StudyLarge GWAS

European

About IGF1

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

rs11111278

GWAS Catalog Trait Associations (2)

cerebellar volume measurement

brain volume

About IGF1

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