rs11126630

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

aggressive behavior quality

Pappa I et al. “A genome-wide approach to children's aggressive behavior: The EAGLE consortium.” American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics 171(5):562-72 (2016)
Allele T
OR 0.03
p 5.0e-8
N 18,988
Major Consortium StudyLarge GWAS
European
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Research that mentions this SNP (1)

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NOS‐I and ‐III gene variants are differentially associated with facets of suicidal behavior and aggression‐related traits
ReviewDan Rujescu et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

A comprehensive review of the genetic basis of aggressive behavior, covering candidate genes in neurotransmitter systems (TPH1, TPH2, SLC6A4, DRD4, COMT, MAOA), hypothalamic-pituitary genes (OXT, OXTR, AVPR1A, AVPR1B), and GWAS findings (LRRTM4 rs11126630 p=5.30×10⁻⁸, CDH13 rs11649622 p=4.19×10⁻⁶, FYN rs2148710 p=2.9×10⁻⁸, DYRK1A). The review concludes that genetic predisposition to aggressive behavior involves multiple genes with small individual effects (1-2% each).

Traits studied:Aggressive behaviorAngerAntisocial behaviorCriminal behaviorHostilitySelf-harmSuicidal behaviorViolence
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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