rs11133665
▶GWAS Catalog Trait Associations (16)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (16)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
tyrosine measurement, serum creatinine amount
Valo E et al. “Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.” Nature Communications 16(1):325 (2025)
Allele A
OR 0.30
p 2.0e-55
N 7,833
Large GWAS
European
tryptophan measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.24
p 4.0e-51
N 4,911
Large GWAS
European
serum creatinine amount, histidine measurement
Valo E et al. “Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.” Nature Communications 16(1):325 (2025)
Allele A
OR 0.31
p 2.0e-39
N 4,969
Large GWAS
European
tyrosine measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.21
p 1.0e-36
N 4,908
Large GWAS
European
methionine sulfone measurement
Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele A
OR 0.27
p 1.0e-35
N 6,136
Large GWAS
European
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.18
p 4.0e-31
N 8,254
Large GWAS
European
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele A
OR 0.21
p 4.0e-33
N 7,921
Large GWAS
multi-ancestry
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.10
p 6.0e-14
N 4,960
Large GWAS
European
kynurenine measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.29
p 1.0e-33
N 4,904
Large GWAS
European
phenylalanine measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.15
p 2.0e-31
N 4,912
Large GWAS
European
urinary metabolite measurement
Raffler J et al. “Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.” Plos Genetics 11(9):e1005487 (2015)
Allele A
OR 0.16
p 2.0e-26
N 3,861
Large GWAS
European
Sekula P et al. “Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease.” Scientific Reports 10(1):10018 (2020)
Allele A
OR 0.17
p 6.0e-12
N 4,863
Large GWAS
European
Schlosser P et al. “Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.” Nature Genetics 52(2):167-176 (2020)
Allele A
OR 0.17
p 2.0e-15
N 1,221
Large GWAS
histidine measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele A
OR 0.22
p 1.0e-21
N 4,911
Large GWAS
European
1-Methylhistidine measurement
Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele A
OR 0.16
p 3.0e-21
N 8,226
Large GWAS
European
Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele A
OR 0.19
p 2.0e-17
N 6,136
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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