rs111434821
This variant is located in the TRIP12 gene.
▶ClinVar annotation
not provided; TRIP12-related disorder; Malignant tumor of esophagus; Nonpapillary renal cell carcinoma; Lung cancer; Cervical cancer; Uterine carcinosarcoma; Acute myeloid leukemia; Clear cell carcinoma of kidney; Colon adenocarcinoma; Sarcoma; Gastric cancer; Uterine corpus endometrial carcinoma; Ovarian serous cystadenocarcinoma; Melanoma
View on ClinVar →About TRIP12
The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
View all TRIP12 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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