rs11145617
This variant is located in the GNAQ gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
gestational age
Pasanen A et al. “Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.” Plos Genetics 19(10):e1010982 (2023)
Allele G
OR 5.64
p 2.0e-8
N 68,732
Meta-analysisLarge GWAS
European
About GNAQ
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
View all GNAQ variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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