rs11150606

This is a protein-altering variant in the PRSS53 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of serine protease 53 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.49
p 6.0e-210
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations
AssociationN=3,608Sijie Wu et al.(2016)· Human Genetics

Genome-wide association study of hair straightness in 2899 Han Chinese and 709 Uyghurs identifies EDAR (rs3827760) as the predominant gene affecting this phenotype in East Asians (P = 4.67 × 10⁻¹⁶ in Han Chinese, P = 1.75 × 10⁻¹² in Uyghurs), explaining 3.66-5.51% of variance. In Uyghurs, both EDAR (OR 0.415) and TCHH (rs11803731, OR 0.575) are associated with hair straightness, but EDAR has a greater effect and shows no significant interaction with TCHH (P = 0.645).

Traits studied:Hair straightnessHair texture
PubMedDOIMetascience Observatory

About PRSS53

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

View all PRSS53 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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