rs11154792
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▶Research that mentions this SNP (1)
▶Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) studyMeta-analysisN=159,940Jihye Ryu et al.(2012)· Human Mutation
Transethnic genome-wide meta-analysis in 159,940 individuals identified 60 common genetic variants associated with HbA1c levels. Variants were classified as glycemic (19), erythrocytic (22), or unclassified (19) based on their biological mechanisms. Glycemic variants were associated with higher type 2 diabetes risk (OR=1.05 per allele, p=3×10⁻²⁹), while erythrocytic variants were not. The X-linked G6PD G202A variant showed a large effect in African Americans (0.81% HbA1c reduction per allele) but minimal effects in other ancestries, potentially causing 2% of African American T2D cases to remain undiagnosed when using HbA1c screening.
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