rs11166276

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cardiovascular measurement

Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)

Allele C

OR 0.05

p 3.0e-30

N 98,645

Large GWAS

European

aortic stenosis, aortic valve calcification

Small AM et al. “Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.” Circulation 147(12):942-955 (2023)

Allele T

OR 1.15

p 2.0e-24

N 300,182

Major Consortium StudyLarge GWAS

European

Bicuspid aortic valve

Thériault S et al. “Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.” Circulation (2026)

Allele T

OR 1.21

p 1.0e-18

N 65,677

Large GWAS

European

aortic stenosis

Kany S et al. “Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk.” Nature Genetics 58(1):47-56 (2026)

Allele C

OR 0.06

p 6.0e-67

N 205,483

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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